Roles for PI(3,5)P(2) in nutrient sensing through TORC1

TORC1, a conserved protein kinase, regulates cell growth in response to nutrients. Localization of mammalian TORC1 to lysosomes is essential for TORC1 activation. Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), an endosomal signaling lipid, is implicated in insulin-dependent stimulation of TORC...

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Autors principals: Jin, Natsuko, Mao, Kai, Jin, Yui, Tevzadze, Gela, Kauffman, Emily J., Park, Sujin, Bridges, Dave, Loewith, Robbie, Saltiel, Alan R., Klionsky, Daniel J., Weisman, Lois S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967979/
https://ncbi.nlm.nih.gov/pubmed/24478451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-01-0021
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