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Highlighting the Role of Polymer Length, Carbohydrate Size, and Nucleic Acid Type in Potency of Glycopolycation Agents for pDNA and siRNA Delivery

While nucleic acids such as small interfering RNA (siRNA) and plasmid DNA (pDNA) are promising research tools and therapeutic modalities, their potential in medical applications is limited by a fundamental mechanistic understanding and inadequate efficiency. Herein, two series of carbohydrate-based...

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Detalhes bibliográficos
Main Authors: Xue, Lian, Ingle, Nilesh P., Reineke, Theresa M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967859/
https://ncbi.nlm.nih.gov/pubmed/24028685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm401026n
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