Natural History of Cone Disease in the Murine Model of Leber Congenital Amaurosis Due to CEP290 Mutation: Determining the Timing and Expectation of Therapy

BACKGROUND: Mutations in the CEP290 (cilia-centrosomal protein 290 kDa) gene in Leber congenital amaurosis (LCA) cause early onset visual loss but retained cone photoreceptors in the fovea, which is the potential therapeutic target. A cone-only mouse model carrying a Cep290 gene mutation, rd16;Nrl(−...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Boye, Shannon E., Huang, Wei-Chieh, Roman, Alejandro J., Sumaroka, Alexander, Boye, Sanford L., Ryals, Renee C., Olivares, Melani B., Ruan, Qing, Tucker, Budd A., Stone, Edwin M., Swaroop, Anand, Cideciyan, Artur V., Hauswirth, William W., Jacobson, Samuel G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966841/
https://ncbi.nlm.nih.gov/pubmed/24671090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092928
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker