Natural History of Cone Disease in the Murine Model of Leber Congenital Amaurosis Due to CEP290 Mutation: Determining the Timing and Expectation of Therapy

BACKGROUND: Mutations in the CEP290 (cilia-centrosomal protein 290 kDa) gene in Leber congenital amaurosis (LCA) cause early onset visual loss but retained cone photoreceptors in the fovea, which is the potential therapeutic target. A cone-only mouse model carrying a Cep290 gene mutation, rd16;Nrl(−...

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Главные авторы: Boye, Shannon E., Huang, Wei-Chieh, Roman, Alejandro J., Sumaroka, Alexander, Boye, Sanford L., Ryals, Renee C., Olivares, Melani B., Ruan, Qing, Tucker, Budd A., Stone, Edwin M., Swaroop, Anand, Cideciyan, Artur V., Hauswirth, William W., Jacobson, Samuel G.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966841/
https://ncbi.nlm.nih.gov/pubmed/24671090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092928
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