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Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes
BACKGROUND AND PURPOSE: The global heterozygous glucokinase (GK) knockout (gk(wt/del)) male mouse, fed on a high-fat (60% by energy) diet, has provided a robust and reproducible model of hyperglycaemia. This model could be highly relevant to some facets of human type 2 diabetes (T2D). We aimed to in...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966744/ https://ncbi.nlm.nih.gov/pubmed/24772483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12498 |
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