Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes

BACKGROUND AND PURPOSE: The global heterozygous glucokinase (GK) knockout (gk(wt/del)) male mouse, fed on a high-fat (60% by energy) diet, has provided a robust and reproducible model of hyperglycaemia. This model could be highly relevant to some facets of human type 2 diabetes (T2D). We aimed to in...

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Autores principales: Baker, D J, Atkinson, A M, Wilkinson, G P, Coope, G J, Charles, A D, Leighton, B
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966744/
https://ncbi.nlm.nih.gov/pubmed/24772483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12498
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