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Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966703/ https://ncbi.nlm.nih.gov/pubmed/24569140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045443 |
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