The structural basis of fatty acid elongation by the ELOVL elongases

Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalysed by the 3-keto acyl-CoA synthases (in mammals, ELOVL elongases). Although ELOVLs are implicated in common diseases includ...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Nie, Laiyin, Pascoa, Tomas C., Pike, Ashley C. W., Bushell, Simon R., Quigley, Andrew, Ruda, Gian Filippo, Chu, Amy, Cole, Victoria, Speedman, David, Moreira, Tiago, Shrestha, Leela, Mukhopadhyay, Shubhashish M.M., Burgess-Brown, Nicola A., Love, James D., Brennan, Paul E., Carpenter, Elisabeth P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611377/
https://ncbi.nlm.nih.gov/pubmed/34117479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-021-00605-6
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