Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity?([Image: see text])

When investigating the potential for xanthine oxidase (XO)-mediated metabolism of a new chemical entity in vitro, selective chemical inhibition experiments are typically used. Most commonly, these inhibition experiments are performed using the inhibitor allopurinol (AP) and commercially prepared hum...

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Bibliographische Detailangaben
Hauptverfasser: Barr, John T., Choughule, Kanika V., Nepal, Sahadev, Wong, Timothy, Chaudhry, Amarjit S., Joswig-Jones, Carolyn A., Zientek, Michael, Strom, Stephen C., Schuetz, Erin G., Thummel, Kenneth E., Jones, Jeffrey P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
Schlagworte:
Accelerated Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965898/
https://ncbi.nlm.nih.gov/pubmed/24430612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.056374
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