Ezetimibe Inhibits Hepatic Niemann-Pick C1-Like 1 to Facilitate Macrophage Reverse Cholesterol Transport in Mice

Eitemau Tebyg

• Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver
  gan: Tang, Weiqing, et al.
  Cyhoeddwyd: (2011)
• Hepatic Niemann-Pick C1–like 1 regulates biliary cholesterol concentration and is a target of ezetimibe
  gan: Temel, Ryan E., et al.
  Cyhoeddwyd: (2007)
• Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1
  gan: Jia, Lin, et al.
  Cyhoeddwyd: (2010)
• Role of Phospholipid Transfer Protein in High-Density Lipoprotein– Mediated Reverse Cholesterol Transport
  gan: Yazdanyar, Amirfarbod, et al.
  Cyhoeddwyd: (2011)
• The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
  gan: Garcia-Calvo, Margarita, et al.
  Cyhoeddwyd: (2005)