Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

A preclinical model of invasive bladder cancer was developed in human mucin 1 (MUC1) transgenic (MUC1.Tg) mice for the purpose of evaluating immunotherapy and/or cytotoxic chemotherapy. To induce bladder cancer, C57BL/6 mice (MUC1.Tg and wild type) were treated orally with the carcinogen N-butyl-N-(...

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Main Authors: Vang, Daniel P., Wurz, Gregory T., Griffey, Stephen M., Kao, Chiao-Jung, Gutierrez, Audrey M., Hanson, Gregory K., Wolf, Michael, DeGregorio, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: MyJove Corporation 2013
Fag:
Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965342/
https://ncbi.nlm.nih.gov/pubmed/24300078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/50868
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