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P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells

Objectives. The mechanism underlying the regulation of glucolipotoxicity-induced apoptosis by MAPKs was examined in INS-1 cells. Methods. The rat insulinoma cell line INS-1 was cotreated with glucose (30 mM) and palmitic acid (0.2 mM) (GLU+PA). Apoptosis was assessed by cell morphology and detection...

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Detalhes bibliográficos
Main Authors: Zhou, Lingli, Cai, Xiaoling, Han, Xueyao, Ji, Linong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964802/
https://ncbi.nlm.nih.gov/pubmed/24734256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/834528
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