Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients

Peroxynitrite (ONOO(−)) contributes to coronary microvascular dysfunction in diabetes mellitus (DM). We hypothesized that in DM, ONOO(−) interferes with the function of coronary endothelial caveolae, which plays an important role in nitric oxide (NO)-dependent vasomotor regulation. Flow-mediated dil...

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Autors principals: Cassuto, James, Dou, Huijuan, Czikora, Istvan, Szabo, Andras, Patel, Vijay S., Kamath, Vinayak, Belin de Chantemele, Eric, Feher, Attila, Romero, Maritza J., Bagi, Zsolt
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Complications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964507/
https://ncbi.nlm.nih.gov/pubmed/24353182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0577
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