ST2 Deficiency Does Not Impair Type 2 Immune Responses during Chronic Filarial Infection but Leads to an Increased Microfilaremia Due to an Impaired Splenic Microfilarial Clearance

BACKGROUND: Interactions of the Th2 cytokine IL-33 with its receptor ST2 lead to amplified Type 2 immune responses. As Type 2 immune responses are known to mediate protection against helminth infections we hypothesized that the lack of ST2 would lead to an increased susceptibility to filarial infect...

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Hoofdauteurs: Ajendra, Jesuthas, Specht, Sabine, Neumann, Anna-Lena, Gondorf, Fabian, Schmidt, David, Gentil, Katrin, Hoffmann, Wolfgang H., Taylor, Mark J., Hoerauf, Achim, Hübner, Marc P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963995/
https://ncbi.nlm.nih.gov/pubmed/24663956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093072
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