Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells

Interleukin-6 (IL-6), a multifunctional cytokine, contributes to proliferation or differentiation of prostate carcinoma cells in a highly cell type-specific manner. Celastrol (3-hydroxy-24-nor-2oxo-1(10),3,5,7-friedelatetrane-29-oic acid), also named as tripterine, is extracted from root of Chinese...

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Hlavní autoři: Chiang, Kun-Chun, Tsui, Ke-Hung, Chung, Li-Chuan, Yeh, Chun-Nan, Chen, Wen-Tsung, Chang, Phei-Lang, Juang, Horng-Heng
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963984/
https://ncbi.nlm.nih.gov/pubmed/24664372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093151
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