Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants

Tumor necrosis factor-alpha (TNF) binds to two receptors: TNFR1/p55-cytotoxic and TNFR2/p75-pro-survival. We have shown that tumor growth in p75 knockout (KO) mice was decreased more than 2-fold in Lewis lung carcinoma (LLCs). We hypothesized that selective blocking of TNFR2/p75 LLCs may sensitize t...

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Bibliographic Details
Main Authors: Sasi, Sharath P., Bae, Sanggyu, Song, Jin, Perepletchikov, Aleksandr, Schneider, Douglas, Carrozza, Joseph, Yan, Xinhua, Kishore, Raj, Enderling, Heiko, Goukassian, David A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963887/
https://ncbi.nlm.nih.gov/pubmed/24664144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092373
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