TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naïve BM-derived TNFR1/p55KO EPCs

Background: Tumor necrosis factor-α (TNF) binds two receptors TNFR1/p55 and TNFR2/p75 and activates several signaling cascades. Ionizing radiation (IR) increases tissue levels of TNF. TNF signaling regulates numerous cytokines and chemokines that are known to mediate radiation-induced non-targeted e...

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Bibliographic Details
Main Authors: Sasi, Sharath P., Song, Jin, Enderling, Heiko, Yan, Xinhua, Goukassian, David A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Poster Session 09: Cellular Signaling Following Particle Exposure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941533/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrt199
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