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Comparison of Genome-Wide Association Methods in Analyses of Admixed Populations with Complex Familial Relationships

Population structure is known to cause false-positive detection in association studies. We compared the power, precision, and type-I error rates of various association models in analyses of a simulated dataset with structure at the population (admixture from two populations; P) and family (K) levels...

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Bibliografiske detaljer
Main Authors: Kadri, Naveen K., Guldbrandtsen, Bernt, Sørensen, Peter, Sahana, Goutam
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963841/
https://ncbi.nlm.nih.gov/pubmed/24662750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088926
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