Weighting sequence variants based on their annotation increases the power of genome-wide association studies in dairy cattle

BACKGROUND: Genome-wide association studies (GWAS) are widely used to identify regions of the genome that harbor genetic determinants of quantitative traits. However, the multiple-testing burden from scanning tens of millions of whole-genome sequence variants reduces the power to identify associated...

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Bibliographic Details
Published in:Genet Sel Evol
Main Authors: Cai, Zexi, Guldbrandtsen, Bernt, Lund, Mogens Sandø, Sahana, Goutam
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511139/
https://ncbi.nlm.nih.gov/pubmed/31077144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-019-0463-9
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