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Lysosome-dependent p300/FOXP3 degradation and limits T(reg) cell functions and enhances targeted therapy against cancers

p300 is one of several acetyltransferases that regulate FOXP3 acetylation and functions. Our recent studies have defined a complex set of histone acetyltransferase interactions which can lead to enhanced or repressed changes in FOXP3 function. We have explored the use of a natural p300 inhibitor, Ga...

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Bibliografiska uppgifter
Huvudupphovsmän: Du, Taofeng, Nagai, Yasuhiro, Xiao, Yan, Greene, Mark I., Zhang, Hongtao
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963828/
https://ncbi.nlm.nih.gov/pubmed/23644046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2013.04.003
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