Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes

BACKGROUND: Genomic imprinting is allelic restriction of gene expression potential depending on parent of origin, maintained by epigenetic mechanisms including parent of origin-specific DNA methylation. Among approximately 70 known imprinted genes are some causing disorders affecting growth, metabol...

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Main Authors: Docherty, Louise E, Rezwan, Faisal I, Poole, Rebecca L, Jagoe, Hannah, Lake, Hannah, Lockett, Gabrielle A, Arshad, Hasan, Wilson, David I, Holloway, John W, Temple, I Karen, Mackay, Deborah J G
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2014
Teme:
Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963529/
https://ncbi.nlm.nih.gov/pubmed/24501229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2013-102116
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