Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement

Adult mesenchymal stem cells, such as dental pulp stem cells, are of great interest for cell-based tissue engineering strategies because they can differentiate into a variety of tissue-specific cells, above all, into osteoblasts. In recent years, epigenetic studies on stem cells have indicated that...

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Autores principales: Paino, Francesca, la Noce, Marcel, Tirino, Virginia, Naddeo, Pasqualina, Desiderio, Vincenzo, Pirozzi, Giuseppe, De Rosa, Alfredo, Laino, Luigi, Altucci, Lucia, Papaccio, Gianpaolo
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
Materias:
Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963447/
https://ncbi.nlm.nih.gov/pubmed/24105979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1544
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