A Potential New Target for Asthma Therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma

BACKGROUND: Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental asthma. METHODS: ADAM10 was blocked either by using...

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Hauptverfasser: Mathews, Joel A., Ford, Jill, Norton, Sarah, Kang, Dae-Joong, Dellinger, Anthony, Gibb, David R., Ford, Andrew Q., Massay, Hugh, Kepley, Christopher L., Scherle, Peggy, Keegan, Achsah D., Conrad, Daniel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963393/
https://ncbi.nlm.nih.gov/pubmed/21557750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1398-9995.2011.02614.x
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