Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)

Nectin-1 is known to undergo ectodomain shedding by α-secretase and subsequent proteolytic processing by γ-secretase. How secretase-mediated cleavage of nectin-1 is regulated in neuronal cells and how nectin-1 cleavage affects synaptic adhesion is poorly understood. We have investigated α-and γ-secr...

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Bibliographic Details
Main Authors: Kim, Jinsook, Lilliehook, Christina, Dudak, Amanda, Prox, Johannes, Saftig, Paul, Federoff, Howard J., Lim, Seung T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906284/
https://ncbi.nlm.nih.gov/pubmed/20501653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126649
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