Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness

BACKGROUND: The matricellular protein connective tissue growth factor (CCN2) has been implicated in pathological fibrosis, but its physiologic role remains elusive. In vitro, transforming growth factor-β (TGF-β) induces CCN2 expression in mesenchymal cells. Because CCN2 can enhance pro-fibrotic resp...

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Detaylı Bibliyografya
Asıl Yazarlar: Mori, Yasuji, Hinchcliff, Monique, Wu, Minghua, Warner-Blankenship, Matthew, Lyons, Karen M., Varga, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963386/
https://ncbi.nlm.nih.gov/pubmed/18201696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.12.010
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