Bcl-2 level as a biomarker for 13q14 deletion in CLL

BACKGROUND: Deletion 13q14.3 is the most common cytogenetic abnormality in chronic lymphocytic leukemia (CLL). Previously it was reported that miR-15/16 is the target of 13q14 deletions and plays a tumor suppressor role by suppressing Bcl-2. Therefore, Bcl-2 expression was examined more closely to d...

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Hauptverfasser: Degheidy, Heba A., Gadalla, Shahinaz M., Farooqui, Mohammed Z.H., Abbasi, Fatima, Arthur, Diane C., Bauer, Steven R., Wilson, Wyndham H., Wiestner, Adrian, Stetler-Stevenson, MA., Marti, Gerald E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963274/
https://ncbi.nlm.nih.gov/pubmed/23674504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.b.21090
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