Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation

RATIONALE: The heart is exquisitely sensitive to mechanical stimuli in order to rapidly adapt to physiological demands. In muscle lacking dystrophin, such as Duchenne muscular dystrophy (DMD), increased load during contraction triggers pathological responses thought to worsen the disease. The releva...

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Hlavní autoři: Seo, Kinya, Rainer, Peter P., Lee, Dong-ik, Hao, Scarlett, Bedja, Djahida, Birnbaumer, Lutz, Cingolani, Oscar H., Kass, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963144/
https://ncbi.nlm.nih.gov/pubmed/24449818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302614
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