Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients

BACKGROUND: Insulin-like growth factor 1 receptor (IGF1R) represents a novel molecular target in non-small-cell-lung cancer (NSCLC). IGF1R and epidermal growth factor receptor (EGFR) activation are essential to mediate tumor cell survival, proliferation, and invasion. This study investigates the pro...

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Main Authors: Ludovini, V., Flacco, A., Bianconi, F., Ragusa, M., Vannucci, J., Bellezza, G., Chiari, R., Minotti, V., Pistola, L., Tofanetti, F. R., Siggillino, A., Baldelli, E., Sidoni, A., Daddi, N., Puma, F., Varella-Garcia, M., Crinò, L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963139/
https://ncbi.nlm.nih.gov/pubmed/23314677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-2056-y
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