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Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis

Targeting serotonin (5-HT) bioavailability with selective 5-HT reuptake inhibitors (SSRIs) remains the most widely used treatment for mood disorders. However, their limited efficacy, delayed onset of action, and side effects restrict their clinical utility. Endogenous regulator of G-protein signalin...

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Detalhes bibliográficos
Main Authors: Stewart, Adele, Maity, Biswanath, Wunsch, Amanda M., Meng, Fantao, Wu, Qi, Wemmie, John A., Fisher, Rory A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963013/
https://ncbi.nlm.nih.gov/pubmed/24421401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-235648
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