Tissue-expressed B7-H1 Critically Controls Intestinal Inflammation

B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here we show that both human and mouse intestinal epithelium expressed B7-H1 and that B7-H1-deficient mice were highly susceptible to dextran sodium sulfate- or trinitrobenzenesulfonic acid-ind...

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Main Authors: Scandiuzzi, Lisa, Ghosh, Kaya, Hofmeyer, Kimberly A., Abadi, Yael M., Lázár-Molnár, Eszter, Lin, Elaine Y., Liu, Qiang, Jeon, Hyungjun, Almo, Steven C., Chen, Lieping, Nathenson, Stanley G., Zang, Xingxing
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962725/
https://ncbi.nlm.nih.gov/pubmed/24529703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.020
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