Loading...
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium
Pyrvinium pamoate (PP) is a potent non-competitive inhibitor of the androgen receptor (AR). Using a novel method of target identification, we demonstrate that AR is a direct target of PP in prostate cancer cells. We demonstrate that PP inhibits AR activity via the highly conserved DNA binding domain...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3962707/ https://ncbi.nlm.nih.gov/pubmed/24354286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400759d |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|