Structure guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers

An α-helical model peptide (Ac-EAEKAAKE-X-EKAAKEAEK-amide) was used as a template to examine the efficacy of conventional reversed-phase high-performance liquid chromatography (RP-HPLC) in separating peptide analogs with single substitutions (at position X) of diasteromeric amino acids Ile, allo-Ile...

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Bibliographic Details
Main Authors: Huang, YiBing, Pan, Ling, Zhao, LianJing, Mant, Colin T., Hodges, Robert S., Chen, Yuxin
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962695/
https://ncbi.nlm.nih.gov/pubmed/24127254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.3061
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