Quantitation of the Nearest-neighbour Effects of Amino Acid Side-Chains that Restrict Conformational Freedom of the Polypeptide Chain using Reversed-Phase Liquid Chromatography of Synthetic Model Peptides with L- and D-amino Acid Substitutions

Side-chain backbone interactions (or “effects”) between nearest neighbours may severely restrict the conformations accessible to a polypeptide chain and thus represent the first step in protein folding. We have quantified nearest-neighbour effects (i to i + 1) in peptides through reversed-phase liqu...

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Päätekijät: Kovacs, James M., Mant, Colin T., Kwok, Stanley C., Osguthorpe, David J., S.Hodges, Robert
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976429/
https://ncbi.nlm.nih.gov/pubmed/16712857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2006.04.092
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