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Quantitation of the Nearest-neighbour Effects of Amino Acid Side-Chains that Restrict Conformational Freedom of the Polypeptide Chain using Reversed-Phase Liquid Chromatography of Synthetic Model Peptides with L- and D-amino Acid Substitutions
Side-chain backbone interactions (or “effects”) between nearest neighbours may severely restrict the conformations accessible to a polypeptide chain and thus represent the first step in protein folding. We have quantified nearest-neighbour effects (i to i + 1) in peptides through reversed-phase liqu...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976429/ https://ncbi.nlm.nih.gov/pubmed/16712857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2006.04.092 |
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