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Optimization of precursor synthesis, formulation and stability of 1′-[(18) F] fluoroethyl-β-d-lactose ([(18) F]FEL) for preclinical studies in detection of pancreatic cancer

INTRODUCTION: 1′-[(18) F]Fluoroethyl-β-d-lactose ([(18) F]FEL) is a new PET imaging agent for early detection of pancreatic cancer and hepatocellular carcinoma. We previously reported the syntheses of [(18) F]FEL using a bromo- and a tosyl- precursor, followed by an improved method using a nosyl-pre...

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Autors principals: Paolillo, Vincenzo, De Palatis, Louis, Alauddin, Mian M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962678/
https://ncbi.nlm.nih.gov/pubmed/24508409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.01.002
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