Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice

Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity, confers striking protection against diet-induced obesity and type 2 diabetes. However, the physiological relevance of this adiponectin-related plasma protein remains undefined. Here, we used gene targeting to establish...

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Hauptverfasser: Wei, Zhikui, Lei, Xia, Petersen, Pia S., Aja, Susan, Wong, G. William
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962615/
https://ncbi.nlm.nih.gov/pubmed/24473438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00593.2013
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