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Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae
Insulin from islet β-cells maintains glucose homeostasis by stimulating peripheral tissues to remove glucose from circulation. Persistent elevation of insulin demand increases β-cell number through self-replication or differentiation (neogenesis) as part of a compensatory response. However, it is no...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3962607/ https://ncbi.nlm.nih.gov/pubmed/24473439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00686.2013 |
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