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Targeted Overexpression of CKI-Insensitive Cyclin-Dependent Kinase 4 Increases Functional β-Cell Number Through Enhanced Self-Replication in Zebrafish

β-Cells of the islet of Langerhans produce insulin to maintain glucose homeostasis. Self-replication of β-cells is the predominant mode of postnatal β-cell production in mammals, with about 20% of rodent β cells dividing in a 24-hour period. However, replicating β-cells are rare in adults. Induction...

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Sonraí Bibleagrafaíochta
Main Authors: Li, Mingyu, Maddison, Lisette A., Crees, Zachary, Chen, Wenbiao
Formáid: Artigo
Teanga:Inglês
Foilsithe: Mary Ann Liebert, Inc. 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673610/
https://ncbi.nlm.nih.gov/pubmed/23544990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/zeb.2012.0816
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