Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

Protein acetylation has emerged as a major mechanism in regulating cellular metabolism. Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is irreversible and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis....

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Autori principali: Jiang, Wenqing, Wang, Shiwen, Xiao, Mengtao, Lin, Yan, Zhou, Lisha, Lei, Qunying, Xiong, Yue, Guan, Kun-Liang, Zhao, Shimin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962309/
https://ncbi.nlm.nih.gov/pubmed/21726808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.04.028
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