Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

Protein acetylation has emerged as a major mechanism in regulating cellular metabolism. Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is irreversible and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jiang, Wenqing, Wang, Shiwen, Xiao, Mengtao, Lin, Yan, Zhou, Lisha, Lei, Qunying, Xiong, Yue, Guan, Kun-Liang, Zhao, Shimin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962309/
https://ncbi.nlm.nih.gov/pubmed/21726808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.04.028
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