Oligomerization of the Nrdp1 E3 Ubiquitin Ligase Is Necessary for Efficient Autoubiquitination but Not ErbB3 Ubiquitination

Overexpression of the ErbB3 receptor tyrosine kinase protein in breast and other cancers contributes to tumor malignancy and therapeutic resistance. The RBCC/TRIM family RING finger E3 ubiquitin ligase Nrdp1 mediates the ubiquitination of ErbB3 in normal mammary epithelial cells to facilitate recept...

Full description

Saved in:
Bibliographic Details
Main Authors: Printsev, Ignat, Yen, Lily, Sweeney, Colleen, Carraway, Kermit L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961680/
https://ncbi.nlm.nih.gov/pubmed/24519943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527036
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items