The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

Several flavin-dependent enzymes of the mitochondrial matrix utilize NAD(+) or NADH at about the same operating redox potential as the NADH/NAD(+) pool and comprise the NADH/NAD(+) isopotential enzyme group. Complex I (specifically the flavin, site I(F)) is often regarded as the major source of matr...

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Autori principali: Quinlan, Casey L., Goncalves, Renata L. S., Hey-Mogensen, Martin, Yadava, Nagendra, Bunik, Victoria I., Brand, Martin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Bioenergetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961658/
https://ncbi.nlm.nih.gov/pubmed/24515115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545301
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