Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum

DNA topoisomerase I from Plasmodium falciparum (PfTopoI), a potential selective target for chemotherapy and drug development against malaria, is used here, together with human Topo I (HssTopoI), for docking, molecular dynamics (MD) studies and experimental assays. Six synthetic isoflavonoid derivati...

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Hauptverfasser: Cortopassi, Wilian A., Penna-Coutinho, Julia, Aguiar, Anna C. C., Pimentel, André S., Buarque, Camilla D., Costa, Paulo R. R., Alves, Bruna R. M., França, Tanos C. C., Krettli, Antoniana U.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961230/
https://ncbi.nlm.nih.gov/pubmed/24651068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091191
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