The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

β-Catenin has a dual function in cells: fortifying cadherin-based adhesion at the plasma membrane and activating transcription in the nucleus. We found that in melanoma cells, WNT5A stimulated the disruption of N-cadherin and β-catenin complexes by activating the guanosine triphosphatase adenosine d...

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Hauptverfasser: Grossmann, Allie H., Yoo, Jae Hyuk, Clancy, James, Sorensen, Lise K., Sedgwick, Alanna, Tong, Zongzhong, Ostanin, Kirill, Rogers, Aaron, Grossmann, Kenneth F., Tripp, Sheryl R., Thomas, Kirk R., D’Souza-Schorey, Crislyn, Odelberg, Shannon J., Li, Dean Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961043/
https://ncbi.nlm.nih.gov/pubmed/23462101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003398
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