Bile acids activate YAP to promote liver carcinogenesis

Elevated bile acid levels increase hepatocellular carcinoma by unknown mechanisms. Here we show that mice with a severe defect in bile acid homeostasis due to loss of the nuclear receptors FXR and SHP have enlarged livers, progenitor cell proliferation, YAP (Yes Associated Protein) activation, and d...

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Autors principals: Anakk, Sayeepriyadarshini, Bhosale, Manoj, Schmidt, Valentina A., Johnson, Randy L, Finegold, Milton J, Moore, David D
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961013/
https://ncbi.nlm.nih.gov/pubmed/24268772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.030
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