Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage

Chronic inflammation promotes oncogenic transformation and tumor progression. Many inflammatory agents also generate a toxic microenvironment, implying that adaptive mechanisms must be deployed for cells to survive and undergo transformation in such unfavorable contexts. A paradigmatic case is repre...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Collino, Agnese, Termanini, Alberto, Nicoli, Paola, Diaferia, Giuseppe, Polletti, Sara, Recordati, Camilla, Castiglioni, Vittoria, Caruso, Donatella, Mitro, Nico, Natoli, Gioacchino, Ghisletti, Serena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957449/
https://ncbi.nlm.nih.gov/pubmed/29734330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007380
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