The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way

BACKGROUND: The androgen receptor (AR) AR-V7 splice isoform is a constitutively active outlaw transcription factor. Transition of prostate cancer to the castration-resistant phenotype correlates with AR-V7 accumulation, suggesting that prostate cancer progression in patients refractory to convention...

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Hauptverfasser: Mediwala, Sanjay N., Sun, Huiying, Szafran, Adam T., Hartig, Sean M., Sonpavde, Guru, Hayes, Teresa G., Thiagarajan, Perumal, Mancini, Michael A., Marcelli, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961010/
https://ncbi.nlm.nih.gov/pubmed/22821817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22566
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