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Delayed triggering of oestrogen induced apoptosis that contrasts with rapid paclitaxel-induced breast cancer cell death

BACKGROUND: Oestrogen (E(2)) induces apoptosis in long-term E(2)-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E(2) in compar...

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Autors principals: Obiorah, I, Sengupta, S, Fan, P, Jordan, V C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960622/
https://ncbi.nlm.nih.gov/pubmed/24548860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.50
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