Delayed triggering of oestrogen induced apoptosis that contrasts with rapid paclitaxel-induced breast cancer cell death

BACKGROUND: Oestrogen (E(2)) induces apoptosis in long-term E(2)-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E(2) in compar...

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Detalles Bibliográficos
Main Authors: Obiorah, I, Sengupta, S, Fan, P, Jordan, V C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
Assuntos:
Translational Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960622/
https://ncbi.nlm.nih.gov/pubmed/24548860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.50
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