Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells

BACKGROUND: Recently several microRNAs (miRNAs) have been found to be regulated by genistein in cancer cells. In this study, we focused on the gene regulatory effect of genistein on microRNA and its target genes in prostate cancer (PC). METHODS: Initially, we investigated the effect of genistein on...

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Dettagli Bibliografici
Autori principali: Hirata, H, Hinoda, Y, Shahryari, V, Deng, G, Tanaka, Y, Tabatabai, Z L, Dahiya, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
Soggetti:
Molecular Diagnostics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960620/
https://ncbi.nlm.nih.gov/pubmed/24504368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.48
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