Effects of tolcapone on working memory and brain activity in abstinent smokers: A proof-of-concept study

BACKGROUND: Dopamine levels in the prefrontal cortex (PFC) are thought to play an important role in cognitive function and nicotine dependence. The catechol-O-methyltransferase (COMT) inhibitor tolcapone, an FDA-approved treatment for Parkinson’s disease, increases prefrontal dopamine levels, with c...

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Autors principals: Ashare, Rebecca L., Wileyto, E. Paul, Ruparel, Kosha, Goelz, Patricia M., Hopson, Ryan D., Valdez, Jeffrey N., Gur, Ruben C., Loughead, James, Lerman, Caryn
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960598/
https://ncbi.nlm.nih.gov/pubmed/24095246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2013.09.003
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