ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor

Trans-activating response region (TAR) DNA-binding protein of 43 kDa (TDP-43) is an RNA-binding protein that is mutated in familial amyotrophic lateral sclerosis (ALS). Disease-linked mutations in TDP-43 increase the tendency of TDP-43 to aggregate, leading to a corresponding increase in formation o...

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Main Authors: Liu-Yesucevitz, LiQun, Lin, Amy Y., Ebata, Atsushi, Boon, Joon Y., Reid, Whitney, Xu, Ya-Fei, Kobrin, Kendra, Murphy, George J., Petrucelli, Leonard, Wolozin, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960463/
https://ncbi.nlm.nih.gov/pubmed/24647938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2350-13.2014
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